14 beste vacatures voor de functie van postdoctoral researcher in nieuwegein, ut (nieuwe medewerkers gezocht)

Post-doctoral researcher – (tumor)immunology
Prinses Máxima Centrum —Utrecht Oost
- € 4.163 - € 6.098 per maand
- Fulltime
- Doctor
- Engels
- Onderzoek
11 uur
Postdoctoral Researcher “Eating Disorders"
Universiteit Utrecht —Utrecht Oost
- € 3.546 - € 5.538 per maand
- Fulltime
- Doctor
- Engels
- Master
Snel solliciteren
Postdoctoral Researcher Youth, Uncertainty, and Societal Impact
Universiteit Utrecht —Utrecht Oost
- € 3.546 - € 5.538 per maand
- Fulltime
- Doctor
- Engels
- Onderzoek
Snel solliciteren
7 dagen
Postdoctoral Researcher in IgA-like Antibody Development
UMC Utrecht —Utrecht
- € 3.724 - € 5.867 per maand
- Parttime
- Doctor
- Engineering
- Engels
13 dagen
Postdoctoral Researcher in Blue Planet Governance
Universiteit Utrecht —Utrecht Oost
- € 3.546 - € 5.538 per maand
- Fulltime
- Doctor
- Schrijfvaardigheden
- Engels
Snel solliciteren
6 dagen
Research Technician – IgA Antibody Production and Development
UMC Utrecht —Utrecht
- € 3.171 - € 4.492 per maand
- Parttime
- Doctor
- Laboratoriumervaring
- Engels
13 dagen
PhD: does an island’s geologic history predict its ecosystem resilience today?
Universiteit Utrecht —Utrecht Oost
- € 3.059 - € 3.881 per maand
- Fulltime
- Doctor
- Engels
- Master
Snel solliciteren
Post-doc Oncode Accelerator
UMC Utrecht —Utrecht
- € 3.724 - € 5.867 per maand
- Parttime
- Doctor
- Informatica
- Engels
8 dagen
PhD: Fostering mutual learning between science and society in nanomedicine
Universiteit Utrecht —Utrecht Oost
- € 3.059 - € 3.881 per maand
- Fulltime
- Doctor
- Engels
- Onderzoek
Snel solliciteren
PhD position to model the climate of Antarctica until 2300
Universiteit Utrecht —Utrecht Oost
- € 3.059 - € 3.881 per maand
- E-mail
- Doctor
- Master
- Python
Snel solliciteren
2 dagen
Postdoc: Bridging the Molecular Biology and Epidemiology of Cancer Development
Universiteit Utrecht —Utrecht Oost
- € 3.546 - € 5.538 per maand
- E-mail
- Doctor
- Engels
- Analytisch vermogen
Snel solliciteren
Assistant Professor in Paleontology
Universiteit Utrecht —Utrecht Oost
- € 4.728 - € 6.433 per maand
- Fulltime
- Laboratorium
- Doctor
- Engels
Snel solliciteren
6 dagen
PhD: impacts of human-induced air-water pollution on planetary health
Universiteit Utrecht —Utrecht Oost
- € 3.059 - € 3.881 per maand
- Fulltime
- Doctor
- Engels
- Onderzoek
Snel solliciteren
PhD position on Fine Particles in Shallow Groundwater Systems
Universiteit Utrecht —Utrecht Oost
- € 3.059 - € 3.881 per maand
- Fulltime
- Doctor
- Engels
- Master
Snel solliciteren

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Post-doctoral researcher – (tumor)immunology

Prinses Máxima Centrum -
Utrecht Oost

Nu solliciteren

Vacaturegegevens

Fulltime
€ 4.163 - € 6.098 per maand
11 uur geleden

Kwalificaties

Doctor
Engels
Onderzoek
AFAS
Communicatieve vaardigheden
Python

Volledige vacaturetekst

36 uur

4.163 - 6.098

Sluit op 20 juni 2026

You can apply directly via the button on this page. The deadline is June 21, but we encourage you to apply as soon as possible as the process may close earlier if a suitable candidate is found.

Do you want to make an impact? We are seeking a curious and passionate (tumor)immunologist, to unravel resistance to immunotherapy in children with B-cell precursor acute lymphoblastic leukemia.

The Project

B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common childhood cancer with ~100 newly diagnosed children yearly in the Netherlands and approximately 3,000 new cases in Europe. Patients receive risk-adapted combination chemotherapy for 2 up to 3 years, which cures more than 90% of patients in the modern era. For pediatric patients the intensive treatment schedule for several years is accompanied by co-morbidity and may impact quality of life, sometimes extending into adulthood.

Cell-based immunotherapy using the CD19xCD3 bispecific T cell engaging antibody blinatumomab is targeted to BCP-ALL cells and may induce less, or more manageable, off-target effects than conventional chemotherapeutics. However, using ex vivo assays we noticed that a substantial number of bone marrow aspirates taken from newly diagnosed BCP-ALL patients seems to be resistant to blinatumomab. Some of these cases appear to be initially immunosuppressed, while other cases display intrinsic cellular resistance. You will work to identify causes of this resistance in BCP-ALL using both molecular and cellular technologies. We aim to identify candidate genes and pathways for laboratory studies addressing functional causality with immunotherapy response and improvements thereof. Which, upon pre-clinical validation, will be assessed for prognostic and/or therapeutic value in patients.

Den Boer Group

The research group of prof. dr. Monique den Boer (currently comprising ~13 scientific personnel) focusses on identifying features of leukemic cells that can be used to improve the clinical outcome for children with BCP-ALL. We have expertise in pathobiological studies addressing the impact of leukemia-associated genetic alterations/drivers, how these lesions functionally contribute to response or non-response to therapeutic agents and their interaction with the bone marrow microenvironment. The Den Boer group routinely uses many molecular techniques, including (single cell) sequencing, CRISPR gene editing, conventional and spectral flow cytometry, confocal and spatial imaging, and organ-on-chip cell migration assays. Our 30-year track record in preclinical/translational childhood leukemia research has directly resulted in knowledge translation via new clinical treatment protocols. Our journey continues to further improve the specificity of childhood ALL therapy with goals of optimal efficacy and quality of life.

The Princess Máxima Center

In the Netherlands, nearly all childhood cancer research and clinical care are concentrated in a single institute, the Princess Máxima Center for Pediatric Oncology, in Utrecht. With approximately 600 children each year diagnosed with cancer in the Netherlands and 150 children suffering from relapse each year, our comprehensive center comprises the largest pediatric oncology institute in Europe. This provides a unique opportunity for the Netherlands to contribute to the world-wide effort in understanding and improving outcome for children with cancer.

Education and skills

PhD in immunology, ideally cancer/tumor immunology
A high level of scientific thinking and in-depth knowledge of immunological processes
Demonstrated experience in cell biological and molecular technologies
Demonstrated experience with programming in Python and/or R.
A clear interest in pre-clinical/translational cancer research
A strong motivation, excellent problem-solving attitude and eagerness to learn
Attention to detail, flexibility, and good organizational and data management skills
A team player with the ability to work independently, as well as collaboratively, in a multidisciplinary research team
Excellent written and verbal English communication skills

Our offer

We offer a challenging project in an inspiring and inter-disciplinary research environment, which offers opportunities to engage in a wide program of basic, pre-clinical and translational research and which supports the generation of new (own) hypotheses. This postdoctoral position is planned for a minimum of 2 years. You will initially be appointed for a period of 1 year, during which your performance will be evaluated. Your gross monthly salary will start in FWG 60 with a maximum salary of €6.098,- gross a month for a fulltime working week (36 hours), supplemented with 8.33% holiday allowance and 8.33% end-of-year bonus. The Princess Máxima Center operates according to the collective labor agreement ‘CAO ziekenhuizen’.

Sollicitatieprocedure

Stap 1
Vertel ons wie je bent
Upload je cv en motivatie en vertel ons wie je bent en waarom deze functie bij je past. Via ons AFAS-portaal volg je eenvoudig de status van je sollicitatie.

Stap 2
We bekijken je sollicitatie
We nemen je sollicitatie zorgvuldig door en informeren je over de volgende stap.

Stap 3
Kennismaken en vervolgstappen
In een eerste gesprek maken we kennis en verkennen we samen of er een match is. Daarna bespreken we de vervolgstappen richting jouw start bij het Máxima.

More information?

For more information, please contact dr. Cesca van de Ven. Please note that you provide an up-to-date resume/CV, a short motivation letter (maximum one A4) and contact information of 2-3 references to your application as incomplete applications will not be considered.

Cesca van de Ven

postdoc

[email protected]

Nu solliciteren

Verfijn je zoekopdracht

postdoctoral researcher vacatures in nieuwegein, ut

Post-doctoral researcher – (tumor)immunology

Postdoctoral Researcher “Eating Disorders"

Postdoctoral Researcher Youth, Uncertainty, and Societal Impact

Postdoctoral Researcher in IgA-like Antibody Development

Postdoctoral Researcher in Blue Planet Governance

Research Technician – IgA Antibody Production and Development

PhD: does an island’s geologic history predict its ecosystem resilience today?

Post-doc Oncode Accelerator

PhD: Fostering mutual learning between science and society in nanomedicine

PhD position to model the climate of Antarctica until 2300

Postdoc: Bridging the Molecular Biology and Epidemiology of Cancer Development

Assistant Professor in Paleontology

PhD: impacts of human-induced air-water pollution on planetary health

PhD position on Fine Particles in Shallow Groundwater Systems

Ik wil de nieuwste vacature-alerts ontvangen voor de functie van postdoctoral researcher in nieuwegein, ut

The Project

Den Boer Group

Education and skills

Our offer

Sollicitatieprocedure

Vertel ons wie je bent

We bekijken je sollicitatie

Kennismaken en vervolgstappen

More information?

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