20 beste vacatures voor de functie van computer vision in katwijk aan den rijn (nieuwe medewerkers gezocht)

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PhD candidate Genetic Susceptibility in Stem Cell-Derived Organoid Safety Testing

Universiteit Leiden -
Leiden

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Vacaturegegevens

Fulltime
€ 3.059 - € 3.881 per maand

Secundaire arbeidsvoorwaarden

Sabbatical

Kwalificaties

Doctor
Schrijfvaardigheden
Engels
Onderzoek
Master
Bachelor
Farmacie

Volledige vacaturetekst

Job requisition Id: 16775

Job type: PhD positions

Contract hours min: 38

Contract hours max: 38

Location: Leiden

Applying is possible until: 21 augustus 2026

Teaser Text

The Faculty of Science and the Division of Cell Systems and Drug Safety is looking for a:

PhD candidate Genetic Susceptibility in Stem Cell-Derived Organoid Safety Testing

Why do people respond differently to harmful substances, and why are some individuals more sensitive to organ damage? This PhD project addresses these fundamental questions by investigating human toxicodynamic variability; the differences in how cells respond to chemical stress. These differences are partly driven by genetic variation, which influences cellular pathways involved in toxicity. Understanding this variation is essential for developing future safety testing strategies that reflect real human diversity.

What you will do

In this project, you will work with human induced pluripotent stem cells (iPSCs) and primary cells derived from donors with different (genetic) backgrounds. By differentiating these stem cells into organ specific cell types and 3D organoids together with CRISPR technology, you will study how genetic variants shape cellular responses to chemical exposure. Combined with advanced detection tools that visualize cellular stress responses, this approach allows you to map how individual’s background translate into toxicodynamic variability.

The project serves as a proof of concept for integrating human variability into next‑generation in vitro safety testing. The knowledge generated will contribute to more accurate risk estimation and support the development of chemical safety assessments that better reflect human diversity.

What you bring

MSc in (Bio)-pharmaceutical Sciences, Biomedical Sciences or Biology
Expertise in (human) induced pluripotent stem cell culture, 3D in vitro systems, molecular and cell biology, gene editing, microscopy, cell signaling
Interest in bioinformatics
Written and oral proficiency in English
Excellent scientific writing skills
Enthusiastic and ambitious
Independent thinker
Team player

Where you will work

Curiosity and passion for science are what connect our people: the desire to know, understand, interpret, explain and create. Our mission is to provide excellent teaching and research across the full breadth of the sciences, contributing to solutions for major societal challenges. Our eight institutes, ranging from mathematics, computer science, astronomy, physics, chemistry, and biopharmaceutical sciences to biology and environmental sciences, along with the Lorentz Center and the Hortus botanicus, form the backbone of our faculty and have a strong mutual interconnectedness.

We work in a safe, stimulating and international environment where people work and study with pleasure and passion, and where building connections and collaboration, both within and beyond the faculty, are a clear choice. The faculty has over 2,700 staff members and more than 6,000 students enrolled in nine bachelor's and fifteen master's programmes. We are located in the heart of the Bio Science Park, one of Europe’s largest science parks, where academia and industry meet.

For more information, see: https://www.universiteitleiden.nl/en/science

What we offer

We offer a full-time (1.0 FTE, 38 hours) 4-year term position. Salary range from € 3.059,- to € 3.881,- gross per month (PhD student, pay scale P) in accordance with the Collective Labour Agreement for Dutch Universities. We aim to employ more women in areas where they are underrepresented. Women are therefore especially invited to apply.

Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses (8.3 %), training and career development and sabbatical leave. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. Candidates from outside the Netherlands may be eligible for a substantial tax break. For more information about employment conditions, see https://www.universiteitleiden.nl/en/working-at/job-application-procedure-and-employment-conditions

All our PhD students are embedded in the Leiden University Graduate School of Science. Our graduate school offers several PhD training courses at three levels: professional courses, skills training and personal effectiveness. In addition, advanced courses to deepen scientific knowledge are offered by the research school.

What we value

Promoting an inclusive community is central to Leiden University’s values and vision. We strive to be an open community in which all students and staff members feel valued and respected, and are able to fully develop themselves. We consider an inclusive academic environment, where students and staff can share their experiences and viewpoints, to be essential for the development of talent.

Want to apply or find out more?

Enquiries can be made to Dr. Marije Niemeijer ([email protected]; +31 71 5275919). If you have any questions about the procedure, please contact the secretariat of the Division of Cell Systems and Drug Safety, Marjolijn Lugthart ([email protected]; +31 71 5276270). Information about the faculty of science can be found at http://www.science.leidenuniv.nl/index.php/english/ and about Leiden University at http://www.vacancies.leiden.edu/ .

To apply for this vacancy, please submit your application online via the blue button in our application system.

Please ensure that you upload the following additional document quoting the vacancy number:

Motivation letter
Curriculum Vitae
The transcripts of your BSc and MSc studies to date
A copy of your (draft) Master’s thesis
Preferably 2 reference letters

Only applications received before 21 August 2026 can be considered.

Starting date: fall 2026, flexible.

Information at a Glance

Faculty / Unit: The Faculty of Science

Contact with (Name + position): D. Marije Niemeijer, Assistant Professor

Contact Email address: [email protected]

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Verfijn je zoekopdracht

computer vision vacatures in katwijk aan den rijn

PhD candidate Genetic Susceptibility in Stem Cell-Derived Organoid Safety Testing

Assistant/Associate Professor in Computer Vision and Deep Learning

Consultant AI

Associate II Manufacturing, Cell Therapy

Scientific Programmer / Post-Doctoral Researcher on Project Hippocampus: The Future of OpenML

Post-Doctoral Researcher on Applications of Control-flow Equivalence to Systems and Security

Automation Scientist (Immunology, BioTech)

Engineer Commissioning, Qualification & Validation (CQV)

Manager - IT Quality and Computerized Systems Validation

Full Stack TypeScript Developer

PhD position in modeling the mechanical regulation of plant development and regeneration (1.0 FTE)

Cybersecurity Sales & Business Development Intern

Solution Architect, Supply Chain Solutions

Postdoctoral Researcher in Data-Efficient Visual Learning

Technische HBO/WO afstudeerstage – Passenger Flow Analyses - Siemens Mobility

Phd Position Multi-Agent Aerial Manipulation for Construction

Research Software Engineer

Specialist, QA Operations Shopfloor

Associate III Manufacturing, Cell Therapy

Associate Professor in Computational Environmental Science (0.8-1.0 FTE)

Ik wil de nieuwste vacature-alerts ontvangen voor de functie van computer vision in katwijk aan den rijn

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