At uniQure, we are delivering on the promise of gene therapy and delivering hope for patients facing urgent unmet medical needs. Every role in our organization carries profound purpose; whether you're in research, operations, access, or support, your contributions impact patients. We're seeking passionate professionals who thrive in high-stakes environments, uphold rigorous quality standards, and share our relentless commitment to transforming the lives of patients. Join us in making the impossible possible, where your expertise becomes a catalyst for life-changing treatments.
uniQure is seeking a motivated and hands‑on Supply Chain Manager - Clinical Operations to help ensure patient‑ready supply for our AAV gene therapy trials. This role is operationally focused and requires consistent on-site presence in Amsterdam to directly support internal laboratory teams and day-to-day supply execution activities. You will play a key role in planning and executing clinical supply activities across planning and scheduling, inventory management, logistics, warehousing, and procurement support in a predominantly outsourced model. Reporting to the Director, Site Head Operations, you will work closely with Clinical Operations, Technical Operations & Quality (TOQ), internal lab teams, external CDMOs, and logistics partners to translate trial plans into reliable, day‑to‑day supply execution. This is a highly visible, cross‑functional role where your work directly supports patients and sites participating in our clinical studies.
Key result areas (major duties, accountabilities and responsibilities)
On-Site Operational Execution & Lab Support
- Provide day-to-day, on-site supply chain support to internal laboratory and technical operations teams, ensuring timely availability of materials, consumables, and documentation
- Execute hands-on inventory management activities, including goods receipt, stock checks, material issuance to labs, and reconciliation activities
- Maintain physical oversight of site inventory, storage conditions, and material flow within the facility
- Act as the primary on-site point of contact for urgent supply issues, enabling rapid resolution to avoid disruption to lab and manufacturing activities
- Perform and/or oversee shipment preparation, packing, and dispatch activities in coordination with logistics providers
- Support label control, material traceability, and chain-of-identity/chain-of-custody requirements where applicable
- Ensure real-time system updates (ERP/inventory systems) aligned with physical material movements
Clinical Supply Planning & Scheduling
- Establish a fit for purpose sourcing and procurement function, initially focused on TOQ but designed to scale across the wider organization
- Own clinical supply plans for assigned studies, translating enrollment, visit schedules, and protocol requirements into clear demand and production plans
- Develop and maintain supply scenarios and what‑if analyses to manage uncertainty in enrollment, site activation, and patient demand
- Create and update supply schedules with CDMOs and packaging/labeling vendors, ensuring alignment with clinical timelines and key milestones
Logistics & Distribution
- Coordinate clinical logistics and distribution activities, including shipments to depots and sites, temperature‑controlled transport, and courier management
- Prepare and maintain shipment plans and documentation to ensure on‑time, compliant delivery to clinical sites
- Support issue resolution related to shipments, temperature excursions, and site‑level supply questions in collaboration with Clinical Operations and Quality
Procurement & Vendor Coordination
- Support sourcing and procurement activities for clinical supply‑related materials and services (e.g., packaging, labels, shippers, ancillary supplies) in partnership with the Sourcing & Procurement Lead
- Manage day‑to‑day coordination with CDMOs, packaging/labeling vendors, 3PLs, and other supply partners to ensure performance against agreed service levels
- Execute purchase requisitions, purchase order management, and follow-up directly within ERP systems, ensuring timely ordering and delivery of materials
Operational Excellence, Systems & Compliance
- Maintain accurate master data and supply parameters in relevant systems (e.g., ERP, inventory/supply planning tools, IRT if applicable)
- Generate and interpret supply chain KPIs (e.g., on-time delivery, backorders, inventory health, lead times) and drive actions to improve performance
- Support continuous improvement initiatives to simplify, standardize, and digitize clinical supply processes.
- Ensure all activities are carried out in compliance with GMP/GDP, SOPs, and study‑specific requirements, partnering with Quality as needed
Cross-Functional Collaboration
- Serve as a key supply chain partner to Clinical Operations, providing clear visibility on supply plans, risks, and mitigation options
- Participate in study and cross‑functional team meetings, representing clinical supply chain and proactively raising constraints and solutions
- Collaborate with TOQ, Regulatory, and Quality on topics related to labeling, country‑specific requirements, import/export, and change control
Qualifications & Skills
- Bachelor’s degree in Supply Chain Management, Business, Life Sciences, Engineering, or related field (or equivalent experience)
- 5-8 years of relevant experience in supply chain within the biopharma industry, with at least 3 years in clinical supply chain, planning, or clinical logistics
- Experience working in GMP/GDP and GxP environments; cell and gene therapy or ATMP experience is a strong plus
- Solid understanding of clinical trial supply concepts (e.g., demand planning, IRT, labeling/packaging, depots, temperature‑controlled logistics)
- Proficiency with ERP and planning tools; experience with inventory management systems and/or IRT is an advantage
- Strong analytical skills with the ability to translate data into clear decisions and recommendations
- Excellent communication and collaboration skills, comfortable working across functions, time zones, and external partners
- Applicants should be a hands‑on supply chain professional who enjoys owning plans end‑to‑end and seeing your work directly impact patients and sites
- A proactive problem‑solver who can anticipate supply risks, propose options, and follow through on actions
- A strong collaborator who builds trust with Clinical Operations, CDMOs, logistics partners, and internal stakeholders
- Organized and detail‑oriented, yet able to keep sight of the bigger clinical and business picture
- Energized by working in a fast‑moving, innovative gene therapy environment and contributing to uniQure’s mission to transform patients’ lives
