The division of Systems Pharmacology and Pharmacy of the Leiden Academic Centre for Drug Research (LACDR) at Leiden University is recruiting a research technician to support drug research involving pharmacological studies in preclinical animal models to characterize concentration-time profiles of drugs and/or metabolites, and biomarkers of efficacy.
The research within our division encompasses a combination of experimental studies and computational modeling, aiming to develop novel strategies towards translational drug development approaches and personalized treatment strategies, with a strong focus on anti-infective therapies. At LACDR we have access to a dedicated facilities for zebrafish and rodent experiments and advanced imaging.
This research technician position will support development and execution of pharmacological experiments in zebrafish embryos and larvae. These zebrafish experiments involve the use of advanced microinjection and microsampling techniques and (automated) fluorescence microscopy, focusing on characterization of drug exposure and efficacy biomarkers. We furthermore foresee the technician may at a later stage support the design and execution of experiments in rodent models linked to future projects. The division’s track record is in studies for brain drug exposure through microdialysis and tissue slice techniques in rats as well as in mouse models of (cardio)metabolic disease, with possible interest in establishing rodent infection models. You work in a team of technicians within the division and closely collaborate with scientific staff members and PhD candidates/postdocs, in a highly collaborative and collegial setting.
